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ATPγS tetralithium salt

Name: ATPγS tetralithium salt
Brand: TargetMol
SKU: T22592
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22592Cas No. 93839-89-5

Alias ATP-gamma-S tetralithium salt

ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.

ATPγS tetralithium salt

🥰Excellent

Catalog No. T22592Alias ATP-gamma-S tetralithium saltCas No. 93839-89-5

ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.

Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$161	In Stock
10 mg	$278	In Stock
25 mg	$593	In Stock
50 mg	$1,020	In Stock
100 mg	$1,770	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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COA HNMR MS

Product Introduction

Bioactivity

Description	ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.
In vitro	ATPγS tetralithium salt enhances intrinsic fluorescence and induces aggregation, thereby increasing spinach Rubisco activating enzyme activity. The concentration dependence of the ATPγS tetralithium salt effect is S-shaped, but at pH 8, the half-saturation requirement of ATPγS tetralithium salt (12 μM) is consistent with that measured indirectly using the fluorescent probe 1-anilinolyl-8-sulfonate. The binding affinities (6 μM) are not much different. [2]
In vivo	METHODS: A mouse model of ALI induced by intratracheal administration of endotoxin/lipopolysaccharide (LPS) and cultured lung ECs was used and treated with ATPγS tetralithium salt (50-100 μM final blood concentration). RESULTS ATPγS tetralithium salt attenuated the inflammatory response, reduced the accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage fluid, and reduced neutrophil infiltration and Evans blue albumin dye extravasation into lung tissue. [3]
Synonyms	ATP-gamma-S tetralithium salt

Chemical Properties

Molecular Weight	546.98
Formula	C₁₀H₁₂Li₄N₅O₁₂P₃S
Cas No.	93839-89-5
Smiles	O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OP([O-])([S-])=O)([O-])=O)([O-])=O)N2C3=NC=NC(N)=C3N=C2.[Li+].[Li+].[Li+].[Li+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (182.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.8282 mL	9.1411 mL	18.2822 mL	91.4110 mL
5 mM	0.3656 mL	1.8282 mL	3.6564 mL	18.2822 mL
10 mM	0.1828 mL	0.9141 mL	1.8282 mL	9.1411 mL
20 mM	0.0914 mL	0.4571 mL	0.9141 mL	4.5706 mL
50 mM	0.0366 mL	0.1828 mL	0.3656 mL	1.8282 mL
100 mM	0.0183 mL	0.0914 mL	0.1828 mL	0.9141 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc